Click Here to return To Results

 

Abnormalities of the Left Temporal Lobe & Thought Disorder in Schizophrenia, A Quantitative MRI Study NEJM 327:604-612, Shenton,M.E.,et al, 1992 See this aricle in Pubmed Article Abstract As compared with the controls,the patients had significant reductions in the volume of gray matter in the left anterior hippocampus-amygdala(by 19 percent[95 percent confidence interval,3 to 36 percent]),the left parahippocampal gyrus(by 13 percent[95 percent confidence interval,3 to 23 percent on the right]),and the left superior temporal gyrus(by 15 percent[ 95 percent confidence interval,5 to 25 percent]).The volume of the left posterior superior temporal gyrus correlated with the score on the thought-disorder index in the 13 patients evaluated(r=-0.81,P=0.001).None of these regional volume decreases were accompanied by a decrease in the volume of the overall brain or temporal lobe.The volume of gray matter in a control region(the superior frontal gyrus)was essentially the same in the patients and controls.Conclusions.Schizophrenia involves localized reductions in the gray matter of the left temporal lobe.The degree of thought disorder is related to the size of the reduction in volume of the left posterior superior temporal gyrus.

Related Tags

(click to filter results - removes previous filter) hippocampus MRI MRI,abnormal schizophrenia temporal lobe temporal lobe,lesion

Click Here to return To Results